Catalog # | 958 |
Type | Recombinant |
Source | E. coli |
Species | Human |
Tag | GST, GFP |
Form | Liquid |
Purity | >95% by SDS PAGE |
Shipping | Ice pack |
Urokinase-type plasminogen activator is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. It converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen.
The PLAU precursor is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain (HMW-uPA). The low molecular weight uPA (LMW-uPA) is generated by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Immunofluorescence, FACS, ELISA, Western blot, protein-protein interactions, Pull-down assay,
Affinity chromatography.
PBS solution 1 mg/ml, contains 10 mM glutation.
-80°C
Analyte specific reagent (ASR) manufactured under ISO 13485
Country of origin: Czech Republic