Introduction
HCMV pp130 (UL57) is a major single-stranded DNA binding protein.
Description
Cytomegalovirus is a member of the herpes viruses. These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are coordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to viral replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be detected in the nuclei and cytoplasm of infected cells.
Application
ELISA, Western blot, LIA, Protein arrays
Purification method
Affinity chromatography.
Formulation
Buffer containing 10mM glutathione. Protein conc. 0.5 mg/ml.
Specificity
Highly immunoreactive fusion protein containing p130 epitopes from immunodominant regions aa 540-601 and aa 1144-1233.
Storage
-80°C. Aliquot upon arrival.
