IGF-1 (Somatomedin C, IGF-I, MGF, Insulin-Like Growth Factor 1)

Introduction

IGF1 human recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain fused to both GST tag.

Description

IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure. Its primary action is mediated by binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R), which is present on many cell types in many tissues.

Application

ELISA, Western blot, protein-protein interactions, Pull-down assay,

Purification method

Affinity chromatography.

Formulation

100mM Tris pH 7.5, 100mM NaCl, 15mM glutathione, 20% glycerol.

Specificity

Binds to IGF-1 receptor.

Storage

-80°C